Genetic analyses of HTLV-I from India and newly identified endemic Loci, Iranian Mashhad and Russia


Yamashita M, Syrtsev A, Achiron A, Shohat B, Gurtsevitch V, Ishida T, Yamamoto N, Takehisa J, Igarashi T, Ibuki K

Int Conf AIDS. 1994 Aug 7-12; 10: 136 (abstract no. PA0162)

 OBJECTIVE: Recently, Mashhadi Jews immigrated from Iran to Israel and people in some part of Russia such as Saharin and Turkmenistan were reported to have high prevalences of HTLV-I. To clarify phylogenetic relations, HTLV-I newly isolated in these loci and India were compared with others reported previously.

 METHODS: A part of LTR sequences was amplified from DNA of seropositive subjects by PCR. Their proviral DNA were sequenced and phylogenetically analyzed.

RESULTS: Phylogenetic analysis evidently showed that both Iranian jewish and Indian HTLV-I were included to subtype A of cosmopolitan type, which consists of those from Caribbean basin, Japan and South America. The isolates of Iran formed a distinct cluster in subtype A, while Indian isolates did not cluster. Sequence analysis of Russian samples are in progress and will be presented.

DISCUSSION AND CONCLUSIONS: The isolates of Iran, India, Japan, Caribbean Basin and South America have the definite relation each other and subtype A is spread over a large area. This finding is interesting in elucidating the origin and evolution of HTLV-I.

Cluster Analysis Emigration and Immigration Evolution Human HTLV-I/*GENETICS/*ISOLATION & PURIF HTLV-I Infections/*EPIDEMIOLOGY/MICROBIOLOGY India/EPIDEMIOLOGY Iran/ETHNOLOGY/EPIDEMIOLOGY Israel/EPIDEMIOLOGY Jews Prevalence *Repetitive Sequences, Nucleic Acid Russia/EPIDEMIOLOGY.